Below is a description of protein folding and how the home user can help in this scientific research. I was a member of it when the Anthrax mailings took place. They immediately started some research on Anthrax and via distributed networking they were able to solve the problem in a couple of weeks--it would have taken years by convential methods. They are currently doing research on diabetes, cancer, etc. The work is out of Stanford University. I have set up a "team" called "MusicalGenes." I would encourage everyone to take advantage and help in the research. Here is how you get going, and the description is below. Distributed Folding Home Page Down Load Screen Saver Here The program takes up minimum resources and is only active when your screen save would be. Once you down load it, then you need to right click on the folding icon (looks like a red gear) and click "configure." You need to click the "User" tab. There is a place for you to insert your name and our team number. Our team number is: 44480 The Stanford Introduction: Our goal: to understand protein folding, protein aggregation, and related diseases What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, Huntington's, and Parkinson's disease. What does [email protected] do? [email protected] is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. We use novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct our approach to examine folding related disease. Results from [email protected] [email protected] exhibit Stanford BMI talk See Prof. Pande's lecture on [email protected] at Xerox PARC How can you help? You can help our project by downloading and running our client software. Our algorithms are designed such that for every computer that joins the project, we get a commensurate increase in simulation speed.