Few today know of the Volstead Act or Prohibition of Alcohol beyond what has appeared in cinema (where for effect was often exaggerated) but the Feds tried annihilation and that didn't work. Too, we've tried paraquat spray on marijuana and cocaine contained vegetation and that has not been effective and subsequently EPA and others have found that smoking such removes the extreme toxicity of paraquat. Presently we are attempting to ban importation of controlled substances but still the majority has not been interdicted by LEO simply because there isn't the budget or manpower to screen all imports ... think of the time it would take to open every package in a Conec shipping container and then repack it for land transport. Really, the sniffer dogs are doing a fantastic job ... you've seen them even in airports ... but they too must be maintained at very high cost and with each is the man/woman officer, but they too go days and weeks without indication of a controlled substance indication, but they did stop me until it was determined that my drugs were medically prescribed. Still, such deterrence is extremely costly and effective IMO less than 1% effective.
At first brush what Dale suggests seems viable. However, to accomplish this we'd need to establish controlled growth by companies that would compete with the untaxed unlawful sources and offer the product at a lower cost to consumers. I might add then to make it unlawful to administer medical treatment for an overdose unless the payment for same is up-front. As stated prior, lock them up or bury them. Now tell me when health insurance companies will provide coverage for a known user of un-prescribed controlled substances or a Federal law requires them to do so. You'll see my name on a gravestone at the end of the street I now live on before that ever happens. FYI the established cemetery and our family plots located in it are at the end of our street. Our names are redacted in case law to, protect our identity.
Certainly 90% plus time I spent on audio and visual surveillance while a NARC was unproductive, but twice I could have been dead had I not received immediate medical care, and in one instance no one was ever apprehended and prosecuted and in the other the shooter got life without parole, not because of me, but because an officer with me was murdered, my circumstance and another were just attempted murder. I never found out if he was the same shooter that killed my partner. Our names are redacted in case law to protect our identities.